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Our Researchers

We work to improve understanding around mental health and substance use across a person’s lifespan. As a team of passionate, caring researchers, we are dedicated to creating positive change across the province of British Columbia and beyond.

Our research scientists hold clinical and/or research roles within BC Mental Health and Substance Use Services, as well as faculty appointments at University of British Columbia and Simon Fraser University.

Many of our researchers are connected with the BC Children's Hospital Research Institute, where they also contribute to significant administrative, teaching and training activities.

Each year, our researchers educate almost 200 trainees, including postdoctoral fellows, graduate and undergraduate students. Assistants and technicians support research activities, and many clinicians and front-line staff also participate in our programs.

Researcher profiles

Primary Area of Research:
Brain, Behaviour and Development
Executive Director, BCMHSUS Research Institute
Professor and Canada Research Chair
UBC Depts of Psychiatry & Medical Genetics


Email: jehannine.austin@ubc.ca
Phone: 604-875-2000 ext. 5943
Mailing Address:
Translational Research Building
Room A3-127 – 3rd Floor
938 W 28th Ave
Vancouver, BC V5Z 4H4

Research Areas

  • Genetics

  • Human development

  • Reproductive health

  • Risk factors

  • Socio-behavioural

About Dr. Austin

Psychiatric disorders are complex conditions that – in broad terms – arise as a result of genetic and environmental vulnerability factors acting together. Progress is now being made towards understanding the causes of these conditions more specifically, and there is an urgent need to translate this into benefit for individuals with psychiatric disorders and their families.

The overall objective of my program of research is to use a clinical genetics perspective to inform the development of novel biological and non-biological interventions to improve outcomes for individuals with psychiatric disorders and to support their families.

I am particularly interested in:

Improving outcomes for people with mental illness and their families by helping them to better understand the causes of mental illness.

Contributing to a better understanding of factors that contribute to the development of postpartum depression, and developing new nutritional interventions to reduce women's risk for postpartum depression.

Modifying healthcare professional's attitudes towards individuals with mental illness.


Affiliate Websites

Twitter @J9_Austin

Translational Psychiatric Genetics Group Twitter

Psychiatric Genetic Counselling Clinic Twitter

Psychiatric Genetic Counselling Facebook

For Patients and Participants

Recent Publications

Find my most recent publications using my ORCID


Selected Publications

Evaluating a unique, specialist psychiatric genetic counseling clinic: uptake and impact. Inglis A, Koehn D, McGillivray B, Stewart E, Austin J. Clinical Genetics 2015, 87(3) 218-224. PMC4318688. PMID: 24773225

A 'cure' for Down syndrome: What do parents want? Lohn Z, Inglis A, Austin J, and Hippman C.  Clinical Genetics 2014. 86(4):310-7 PMC4055389. PMID: 24548046

Parents' Experiences of Receiving their Child's Genetic Diagnosis: A Qualitative Study to Inform Clinical Genetics Practice. Ashtiani S, Makela N, Carrion P, Austin J. American Journal of Medical Genetics 2014, 164(6) 1496-1502 PMC4039554. PMID: 24706543

Genetic counseling for common psychiatric disorders: an opportunity for interdisciplinary collaboration. Austin J, Inglis A, Hadjipavlou G.  American Journal of Psychiatry. 2014, 171 584-585. PMC4111654. PMID: 24788289

Mania and depression in the perinatal period among women with a history of major depressive disorders. Inglis A, Hippman C, Carrion P, Honer WG, Austin JC.  Archives of Womens Mental Health 2014, 17(2) 137-43 PMCID: PMC3961475. PMID: 24402681

Awareness of genetic counseling amongst the Canadian public and perceptions of its purpose. Maio M, Carrion P, Yaremco E, Austin JC.  Journal of Genetic Counseling 2013, 22(6) 762-770. PMCID: PMC3825692. PMID: 23963834

"Nothing is absolute in life": Understanding uncertainty in the context of psychiatric genetic counseling from the perspective of those with serious mental illness. Hippman C, Lohn Z, Inglis A, Ringrose A, Cheek A, Austin JC.  Journal of Genetic Counseling 2013 22(5) 625-632 PMCID: PMC3776779. PMID: 23604904

Discussing the psychiatric manifestations of 22q11.2 deletion syndrome: an exploration of clinical practice among medical geneticists. Morris, E., Inglis, A., Friedman, J., & Austin, J.C. (2013). Genetics in Medicine, 15(9) 713-720. PMCID: 3766374

Descriptive and numeric estimation of risk for psychotic disorders among affected individuals and relatives: implications for clinical practice. Austin, J.C., Hippman, C., & Honer, W.G. (2012). Psychiatric Research, 196(1) 52-6. PMCID: 3723521

Effects of a documentary film on public stigma related to mental illness among genetic counselors. Anderson, K., & Austin, J.C. (2012).  Journal of Genetic Counseling, 21(4):573-81. PMCID: 3706328

What is a "balanced" description? Insight from parents of individuals with Down syndrome. Hippman, C., Inglis, A., & Austin, J.C. (2012).  Journal of Genetic Counseling, 21(1): 35-44. PMCID: 3706329

Lautenbach D., Hiraki, S., Whalen Campion, M., & Austin, J.C. (2012).

Mothers' perspectives on their child's mental illness as compared to other complex disorders in their family: insights to inform genetic counseling practice. Journal of Genetic Counseling, 21: 564-72. PMCID: 3753288

Prenatal testing for Down Syndrome: Perspectives of parents of affected individuals. Inglis A., Hippman, C., & Austin, J.C. (2012). American Journal of Medical Genetics, 158A (4), 743-50.

"Recovery is Such a Huge Word": Understandings of 'Recovery' in People with Bipolar Disorder and Implications for Psychiatric Care. Michalak, E.E., Hole, R., Holmes, C., Velyvis, V., Austin, J.C., Pesut, B., & Hou, S. (2012).  Psychiatric Annals, 42(5), 173-178.

Translating genomic research into care for people with schizophrenia in China. Chan, R.C.K., Austin, J.C., Pearson, V.J, Gong, Q., & Honer, W.G. (2011).  Schizophrenia Research, 131:31-34. PMCID: 3706332

How To Talk To Families About Genetics and Psychiatric Disorders. Peay, H.L., & Austin, J.C. (2011).  New York, NY: WW Norton and Company.

Sex Testing Or Gender Verification: Is There A Difference and Does It Matter?  McBride, R., & Austin, J.C. (2011). Journal of Genetic Counseling, 20, 113-114. PMID: 21165684

Primary Area of Research:
Brain, Behaviour & Development
Investigator, BC Children's Hospital
Associate Professor, Department of Anesthesiology, Pharmacology & Therapeutics, Faculty of Medicine, UBC

Email: albarr@interchange.ubc.ca
Phone: 604-875-2000 ext. 4728
Mailing Address:
BC Children's Hospital Research Institute
Room A3- 125 
950 West 28th Avenue
Vancouver, BC V5Z 4H4

Research Areas

  • Schizophrenia/Psychosis

  • Depression 

  • Animal models 

  • Biological mechanisms

  • Brain morphology

  • Clinical trials

  • Cognition

  • Drug development

  • Drug dosing

  • Drug side-effects 

  • Neuropsychiatry/ Neuropsychology

  • Neurotransmitters

  • Psychostimulants

About Dr. Barr

The central focus of my research is mental health and addictions, with a particular emphasis on psychosis and the medications used in its treatment. My research program is based on a multidisciplinary and translational approach that spans from "bench to bedside," as I maintain strong and highly productive research programs in both clinical and related preclinical research.

Working in collaboration with some of Canada's finest researchers, I study "psychosis" from three different perspectives. These include idiopathic schizophrenia-spectrum disorders, psychostimulant drug-induced psychosis and (most recently) the post-operative delirium that occurs following cardiac surgery. Despite different etiologies and patient populations, these three conditions share many similarities in terms of symptoms and treatment, and all can be studied in a translational manner.

Recent Publications

View Dr. Barr's recent publications on ORCID


Selected Publications

Exercise prevents downregulation of hippocampal presynaptic proteins following olanzapine-elicited metabolic dysregulation in rats: distinct roles of inhibitory and excitatory terminals. Ramos-Miguel A, Honer WG, Boyda HN, Sawada K, Beasley CL, Procyshyn RM, Barr AM. Neuroscience. 2015 Aug 20;301:298-311. doi: 10.1016/j.neuroscience.2015.06.022. Epub 2015 Jun 16.PMID: 26086543

Neuroleptic malignant syndrome: a review from a clinically oriented perspective. Tse L; Barr AM; Vila-Rodriguez F.  Curr Neuropharmacol. Curr Neuropharmacol. 2015;13(3):395-406.PMID: 26411967

Paliperidone Palmitate Long-Acting Injectable Given Intramuscularly in the Deltoid Versus the Gluteal Muscle: Are They Therapeutically Equivalent? Yin J, Collier AC, Barr AM, Honer WG, Procyshyn RM.J Clin Psychopharmacol. 2015 Aug;35(4):447-9. doi: 10.1097/JCP.0000000000000361. Review.PMID: 26061612

Development of a cost-efficient novel method for rapid, concurrent genotyping of 5 common single nucleotide polymorphisms of the Brain Derived Neurotrophic Factor (BDNF) gene by Tetra-Primer Amplification Refractory System. Wang CK, Xu M, Ross CJ, Lo R, Procyshyn RM, Vila-Rodriguez F, White RF, Honer WG, Barr AM. Int J Meth Psychiatr Res. In Press

Treatment of clozapine-associated weight gain: a systematic review. Whitney Z, Procyshyn RM, Fredrikson DH, Barr AM. (2015).  Eur J Clin Pharmacol.71:389-401. PMID: 25627831

Effects of sub-chronic clozapine and haloperidol administration on oxidative stress in rat serum, liver and brain. Andreazza AC; Barakauskas VE, Fazeli S; Feresten A; Shao L; Wei V; Wu CH; Ypsilanti A; Barr AM; Beasley CL. (2015).  Neurosci Lett. 591:36-40.

Response trajectories to clozapine in a secondary analysis of pivotal trials support using treatment response to subtype schizophrenia. Honer WG, Jones AA, Thornton AE, Barr AM, Procyshyn RM, Vila-Rodriguez F (2015).  Can J Psychiatry. 60:19-25. PMID: 25886676

Therapeutic drug levels of second generation antipsychotics in youth: a systematic review. Whitney Z, Boyda HN, Procyshyn RM, Elbe D, Black T, Eslami A, Barr AM. (2015). J Child Adolesc Psychopharmacol. 25:234-245. PMID: 25803501

Postoperative delirium in patients undergoing transcatheter aortic valve replacement: A historical cohort study. Tse L, Bowering JB, Schwarz SKB, Moore RL, Burns KD, Barr AM. (2015). Can J Anesth. 62:22-30. PMID: 25644851

 Incidence and risk factors for impaired mobility in older cardiac surgery patients during the early postoperative period. Tse L, Bowering JB, Schwarz SKW, Moore RL, Sztramko R, Barr AM. (2015). Geriatr Gerontol Int. 15:276-281. PMID: 24617507

Drugs of abuse. In Clinical Handbook of Psychotropic Drugs (ed J Jeffries) 19th edition. Barr AM (2015).

Increased SNARE Protein-Protein Interactions in Schizophrenia Orbitofrontal Cortex. Ramos-Miguel A, Beasley CL, Dwork AJ, Mann J, Rosoklija G, Barr AM, Honer WG. (2014). Biol Psychiatry.

Neurocognitive profiles of marginally housed persons with comorbid substance dependence, viral infection and psychiatric illness. Gicas KM, Vila-Rodriguez F, Paquet K, Barr AM, Procyshyn RM, Lang DJ, Montaner JS, Kradjen M,  Krausz M, MacEwan GW, Smith GN, Panenka WJ, Honer WG, Thornton AE (2014).  J Clin Exp Neuropsychol. 36:1009-1022. PMID: 25380059

Cardiovascular effects of acute treatment with the antipsychotic drug olanzapine in rats. Leung JYT, Pang CCY, Procyshyn RM, Barr AM. (2014).  Vascul Pharmacol. 62:143-149. PMID: 24969105

Improving metabolic and cardiovascular health at an early psychosis intervention program Fredrikson DH, Boyda HN, Tse L, Whitney Z, Pattison MA, Ott FJ, Hansen L, Barr AM. (2014).  in Vancouver, Canada. Front Psychiatry. PMID: 25249985

An evaluation of the effects of the novel antipsychotic drug lurasidone on glucose tolerance and insulin resistance: a comparison with olanzapine. Wu C, Yuen J, Boyda HN, Procyshyn RM, Wang CK, Asiri YI, Pang CCY, Honer WG, Barr AM. (2014).  PLoS One. PMID: 25254366

Managing ADHD and disruptive behaviour disorders with combination psychostimulant and antipsychotic treatment. Elbe D, Barr AM, Honer WG, Procyshyn RM. (2014).  J Psychiatry Neurosci. 39:E 32-33. PMID: 24758945

Prevalence and patterns of antipsychotic use in youth at the time of admission and discharge from an inpatient psychiatric facility. Procyshyn RM, Su J, Elbe D, Liu AY, Panenka WJ, Davidson J, Honer WG, Barr AM. (2014).  J Clin Psychopharmacol. 34:17-22. PMID: 24346744

Clozapine administered once versus twice daily: Does it make a difference? Procyshyn RM, Vila-Rodriguez F, Honer WG, Barr AM. (2014).  Med Hypotheses. 82:225-228.PMID: 24360486

Antidiabetic-drug combination treatment for glucose intolerance in adult female rats treated acutely with olanzapine. Boyda HN, Procyshyn RM, Asiri Y, Wu C, Wang CK, Lo R, Pang CC, Honer WG, Barr AM. (2014).  Prog Neuropsychopharmacol Biol Psychiatry. 48:170-176. PMID: 24140931

Routine exercise ameliorates the metabolic side effects of treatment with the atypical antipsychotic drug olanzapine in rats. Boyda HN, Ramos-Miguel A, Procyshyn RM, Töpfer E, Lant N, Choy HH, Wong R, Li L, Pang CC, Honer WG, Barr AM. (2014).  Int J Neuropsychopharmacol. 17:77-90. PMID: 23953063

 Pharmacological treatment of antipsychotic-induced dyslipidemia and hypertension. Tse L, Procyshyn RM, Fredrikson DH, Boyda HN, Honer WG, Barr AM. (2014). Int Clin Psychopharmacol. 29:125-137. PMID: 24169026

Symptom changes in five dimensions of the Positive and Negative Syndrome Scale in refractory psychosis. Woodward TS, Jung K, Smith GN , Hwang H, Barr AM, Procyshyn RM, Flynn SW, van der Gaag M, Honer WG (2014).  Eur Arch Psychiatry Clin Neurosci. 264:673-682. PMID: 24126470

Insomnia. In Patient Self-Care (ed C Repchinsky), 1st editiion. Procyshyn RM & Barr AM (2014). 33-42.

Depression. In Patient Self-Care (ed C Repchinsky), 1st editiion. Procyshyn RM & Barr AM (2014). 43-50.

 The hotel study: multimorbidity in a community sample living in marginal housing. Vila-Rodriguez F, Panenka WJ, Lang DJ, Thornton AE, Vertinsky T, Wong H, Barr AM, Procyshyn RM, Sidhu JJ, Smith GN, Buchanan T, Krajden M, Krausz M, Montaner JS, MacEwan GW, Honer WG. (2013).Am J Psychiatry. 170:1413-1422.PMID: 23929175

Much of late life cognitive decline is not due to common neurodegenerative pathologies. Boyle PA, Wilson RS, Yu L, Barr AM, Honer WG, Schneider JA, Bennett DA. (2013). Ann Neurol. 74:478-489. PMID: 23798485

Primary Area of Research:
Brain, Behaviour & Development

Investigator, BC Children's Hospital
Associate Professor, Department of Psychiatry, Faculty of Medicine, University of British Columbia


Email: cbeasley@mail.ubc.ca
Phone: 604 875-2000 ext. 4723
Mailing Address:
BC Children's Hospital
4480 Oak Street
Room A3-115
Vancouver, BC V6H 3N1

Research Areas

  • Neuropathology of schizophrenia, bipolar disorder and major depressive disorder
  • White matter
  • Inflammation
  • Antipsychotic Drugs
  • Neurodevelopment
  • Proteomics
  • Histology

About Dr. Beasley

The major aim of my research is to identify changes in the brains of individuals with schizophrenia, bipolar disorder and major depressive disorder that may elucidate the etiology of these disorders and provide clues to novel treatments. Current projects focus on white matter pathology and inflammation. In addition, we study the effects of antipsychotic medications on the brain.

Recent publications

Find most recent publications using my ORCID


Selected Publications

Andreazza AC, Barakauskas VE, Fazeli S, Feresten A, Shao L, Wei V, Wu CH, Barr AM, Beasley CL. Effects of haloperidol and clozapine administration on oxidative stress in rat brain, liver and serum. Neurosci Lett. 2015 591:36-40. PMID: 25684243

Hercher C, Chopra V, Beasley CL. Evidence for morphological alterations in prefrontal white matter glia in schizophrenia and bipolar disorder. J Psychiatry Neurosci. 2014 39(6):376-385. PMID: 24936776

Feresten AH, Barakauskas V, Ypsilanti A, Barr AM, Beasley CL. Increased expression of glial fibrillary acidic protein in prefrontal cortex in psychotic illness. Schizophr Res. 2013 150(1):252-257. PMID: 23911257

Epp JR, Beasley CL, Galea LA. Increased hippocampal neurogenesis and p21 expression in depression: dependent on antidepressants, sex, age, and antipsychotic exposure. Neuropsychopharmacology. 2013 38(11):2297-2306. PMID: 23778854

Barr AM, Wu CH, Wong C, Hercher C, Töpfer E, Boyda HN, Procyshyn RM, Honer WG, Beasley CL. Effects of chronic exercise and treatment with the antipsychotic drug olanzapine on hippocampal volume in adult female rats. Neuroscience. 2013 255:147-157. PMID: 24141179

Vila-Rodriguez, F., Honer, W. G., Innis, S. M., Wellington, C. L., & Beasley, C. L. (2011). ApoE and cholesterol in schizophrenia and bipolar disorder: Comparison of grey and white matter and relation with APOE genotype. Journal of Psychiatry & Neuroscience : JPN, 36(1), 47-55. PMID: 20964956 

Barakauskas, V. E., Ypsilanti, A. R., Barr, A. M., Innis, S. M., Honer, W. G., & Beasley, C. L. (2010). Effects of sub-chronic clozapine and haloperidol administration on brain lipid levels. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 34(4), 669-673. PMID: 20227455

Barakauskas, V. E., Beasley, C. L., Barr, A. M., Ypsilanti, A. R., Li, H. Y., Thornton, A. E., Wong, H., Rosokija, G., Mann, J.J., Mancevski, B., Jakovski, Z., Davceva, N., Illevski, B., Dwork, A.J., Falkai, P., & Honer, W. G. (2010). A novel mechanism and treatment target for presynaptic abnormalities in specific striatal regions in schizophrenia. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 35(5), 1226-1238. PMID: 20072114

Primary Area of Research: Brain, Behaviour and Development
MD, FRCP, FCAHS
Investigator BCMHARI
Centre for Complex Disorders
Jack Bell Chair in Schizophrenia
Professor, Psychiatry University of British Columbia

Email: william.honer@ubc.ca
Telephone: 604–875–3664
Mailing Address:
RM A3-112
950 West 28th Ave.
Vancouver, BC
V52 4H4

http://www.neuroscience.ubc.ca/honer.htm


Research Areas


  • Schizophrenia
  • Alzheimer's Disease
  • Dementia/Neurodegenerative Disorders,
  • Psychotic Disorders
  • Animal Models
  • Biological Mechanisms
  • Brain Imaging
  • Clinical Trials
  • Genetics
  • Human Development
  • Neuropsychiatry/Neuropsychology

About Dr. Honer

Dr. Bill Honer’s primary area of interest is the neurobiology and mechanisms of illness in schizophrenia. Dr. Honer trained in medicine at Queen's University in Kingston, Ontario and received his MD in 1984. Following a year of internal medicine training at Vancouver General Hospital, he was a resident in psychiatry at the New York State Psychiatric Institute / Columbia University for 3 years. During the final year of his residency program, and for the next 3 years, Dr. Honer was a research fellow at Columbia University and the Albert Einstein College of Medicine, where he was a member of Dr. Peter Davies' neuropathology research group. Dr. Honer moved to Vancouver in 1991.

In addition to his extensive contributions on the etiology and pathophysiology of schizophrenia, he has studied brain structure and treatment response in first-episode and treatment refractory patients.

Dr. Honer received a Scientist Award from CIHR, and has received both the Young Investigator Award (1997) and the Heinz Lehmann Award (2008) from the Canadian College of Neuropsycho-pharmacology. He is the author of more than 200 peer-reviewed publications and has authored the assessment section of the Canadian Clinical Practice Guidelines for Schizophrenia.

Recent Publications

View Dr. Honer's recent publications on ORCID

Selected Publications


Vila-Rodriguez, F., Honer, W. G., Innis, S. M., Wellington, C. L., & Beasley, C. L. (2011). ApoE and cholesterol in schizophrenia and bipolar disorder: Comparison of grey and white matter and relation with APOE genotype. Journal of Psychiatry & Neuroscience : JPN, 36(1), 47-55. PMID: 20964956

Torres, I. J., DeFreitas, V. G., DeFreitas, C. M., Kauer-Sant'Anna, M., Bond, D. J., Honer, W. G., Lam, R.W., & Yatham, L. N. (2010). Neurocognitive functioning in patients with bipolar I disorder recently recovered from a first manic episode. TheJournal of Clinical Psychiatry, 71(9), 1234-1242. PMID: 20361907

Smith, G.N., MacEwan, G.W., Kopala, Lang, D.J., Barr, A.M., Honer, W.G., Ehmann, T.S., Good, K., Thornton, A.E., & Neilson, H. (2010) Prenatal tobacco exposure in first-episode psychosis. Schizophrenia Research, 119(1-3), 271–272. PMID: 20116216

Procyshyn, R. M., Honer, W. G., Wu, T. K., Ko, R. W., McIsaac, S. A., Young, A. H., Johnson, J.L., & Barr, A. M. (2010). Persistent antipsychotic polypharmacy and excessive dosing in the community psychiatric treatment setting: A review of medication profiles in 435 canadian outpatients. The Journal of Clinical Psychiatry, 71(5), 566-573. PMID: 20361903

Procyshyn, R. M., Barr, A. M., Flynn, S., Schenk, C., Ganesan, S., & Honer, W. G. (2010). Long-acting injectable risperidone in treatment refractory patients: A 14-week open-label pilot study. Schizophrenia Research, 123(2-3), 273-275. PMID: 20688481

Procyshyn, R. M., Barr, A. M., Brickell, T., & Honer, W. G. (2010). Medication errors in psychiatry: A comprehensive review. CNS Drugs, 24(7), 595-609. PMID: 20356315

Pajonk, F. G., Wobrock, T., Gruber, O., Scherk, H., Berner, D., Kaizl, I., Kierer, A., Müller, S., Oest, M., Meyer, T., Backens, M., Schneider-Axmann, T., Thornton, A.E., Honer, W.G., & Falkai, P. (2010). Hippocampal plasticity in response to exercise in schizophrenia. Archives of General Psychiatry, 67(2), 133-143. PMID: 20124113

Hunter, M. J., Hippman, C., Honer, W. G., & Austin, J. C. (2010). Genetic counseling for schizophrenia: A review of referrals to a provincial medical genetics program from 1968 to 2007. American Journal of Medical Genetics.Part A, 152A(1), 147-152. PMID: 20034078

Chen, E. Y., Hui, C. L., Lam, M. M., Chiu, C. P., Law, C. W., Chung, D. W., Tso, S., Pang, E.P., Chan, K.T., Wong, Y.C., Mo, F.Y., Chan, K.P., Yao, T.J., Hung, S.F., & Honer, W. G. (2010). Maintenance treatment with quetiapine versus discontinuation after one year of treatment in patients with remitted first episode psychosis: Randomised controlled trial. BMJ (Clinical Research Ed.), 341, c4024. PMID: 20724402

Boyda, H. N., Tse, L., Procyshyn, R. M., Honer, W. G., & Barr, A. M. (2010). Preclinical models of antipsychotic drug-induced metabolic side effects. Trends in Pharmacological Sciences, 31(10), 484-497. PMID: 20674990

Primary Area of Research
Brain, Behaviour & Development
Investigator, BC Children's Hospital
Associate Professor, Department of Radiology, Faculty of Medicine, University of British Columbia

Email: dlang@interchange.ubc.ca
Phone: 604-875-2000 ext. 4727
Mailing Address:
Centre for Complex Disorders
Rm A3-124
938 West 28th Avenue 
Vancouver, V5Z 1H4

Research Areas

  • Methamphetamine

  • Psychotic disorders 

  • Schizophrenia

  • Brain imaging

  • Brain morphology 

  • Cognition

  • Dual diagnosis

  • Evaluation research

  • Medication effects

  • Neuropsychiatry/ Neuropsychology

  • Exercise & Brain

About Dr. Lang

In 1995, as a new graduate student in the department of psychiatry, I began investigating the morphological phenomena of schizophrenia and related psychotic disorders. These initial in-vivo investigations involved the application of CT (Computed Tomography) imaging to examine phenotypic characteristics of brain morphology in families affected by schizophrenia. Since that time, my research has moved forward into multi-modal applications of MRI (magnetic resonance imaging) to investigate the effects of antipsychotic medications on brain structure in schizophrenia, the relationships between structure, symptoms and cognition in psychotic disorders and first-episode psychosis, and more recently, the interactions between substance abuse, psychosis and systemic infections on brain morphology.

Currently, all my neuroimaging research data are obtained at UBC on the high-field research scanner, which produces exceptionally high quality scans and gives researchers the capability to examine physiological, biochemical and physical markers in the brain. This has allowed me, along with the residents and graduate students I work with, to examine the neurocircuitry and metabolic characteristics of psychotic disorders using diffusion tensor imaging and susceptibility-weighted imaging. My current projects involve the investigation of the effects of exercise on hipppocampal volume and vascularization in chronic schizophrenia patients and in adolescent psychosis patients. Additionally, I am involved in a large longitudinal imaging study of multi-diagnosis addiction, psychosis and infection subjects over the course of 5-8 years.  Some of the goals of this study include investigating the interactions of life circumstances, addiction, mental illness and physical illnesses in an urban population, and how these interactions have affected quality of life, health care access, persistence of mental disorder/addictions and neurobiological integrity.


Selected Publications

Relationship between body mass index and hippocampal glutamate/glutamine in bipolar disorder. Bond DJ, da Silveira LE, MacMillan E, Torres I, Lang DJ, Su W, Honer WG, Lam R, and Yatham LN 2015.  Brit. J. Psychiat (In Press)

Hippocampal subfield volumes in first-episode and chronic schizophrenia. Kawano M, Sawada K, Shimodera S, Ogawa Y, Kariya S, Lang DJ, Inoue S, and Honer WG. Feb 6,  2015.  PLoS One- DOI: 10.1371/journal.pone.0117785. PMID: 25658118

Cortical morphology and early adverse events in first-episode psychosis. Smith GN, Thornton AE, Lang DJ, MacEwan GW, Kopala LC, Su W, and Honer WG.  Psychol Med. Accepted Nov 18, 2014. PMID: 25499574

Neurocognitive profiles of marginally housed persons with co-morbid substance dependence, viral infection and psychiatric illness. Gicas K, Vila-Rodriguez F, Paquet K, Barr AM, Procyshyn R, Lang DJ, Smith GN, Baitz H, Giesbrecht C, Montaner J, Krajden M, MacEwan GW, Panenka W, Honer WG, and Thornton AE. (Sept) 2014.  J of Clin & Exptl Neuropsych, 36(10): 1009-1022. PMID: 25380059

Body mass index-related regional grey and white matter volume reduction in first-episode mania patients. Bond DJ, Ha TH, Lang DJ, Su W, Torres IJ, Honer WG, Lam RW and Yatham LY. Biological Psychiatry, Vol 76(2): 138-145. 2013.PMID: 24120119

Profiles of individuals seeking psychiatric help for psychotic symptoms linked to methamphetamine abuse - Baseline results from MAPS (Methamphetamine and Psychosis Study). Lecomte, T., Mueser, K.T., MacEwan, G.W., Laferriere-Simard, M.C., Thornton, A.E., Buchanan, T., Goldner, E., Brink, J., Ehmann, T.S., Lang, D.J., Kang, S., Barr, A.M., & Honer, W.G. (2010).  Ment. Health & Subst Use, 3(3), 168-181. PMID:

Prenatal tobacco exposure in first-episode psychosis. Smith, G.N., MacEwan, G.W., Kopala, Lang, D.J., Barr, A.M., Honer, W.G., Ehmann, T.S., Good, K., Thornton, A.E., & Neilson, H. (2010) Schizophrenia Research, 119(1-3), 271–272. PMID: 20116216

 Localization of Subthalamic Nucleus: Optimization with susceptibility-weighted phase MR Imaging. Vertinsky, A.T., Coenen, V.A., Lang, D.J., Kolind, S., Honey, C.R., Li, D. & Rauscher, A. (2009). AJNR. 30, 1717-1724. PMID: 19509077

A family-based association study of the myelin-associated glycoprotien and 2',3'-cyclic nucleotide 3'-phosphodiesterase genes with schizophrenia. Voineskos A.N., de Luca, V., Bulgin, N., van Adrichem, Q., Shaikh, S., Lang, D.J., Honer, W.G., & Kennedy, J.L. 2008. Psychiatric Genetics, 18(3), 143- 146. PMID: 18496213

 MAG gene variation and cortical gray matter volume in first episode schizophrenia. Voineskos, A.N., Lang, D.J., Zai, G., Bulgin, N., Shaikh, S., Su, W., Kopala, L.C., MacEwan, G.W., Thornton, A.E., Smith, G.N., Austin, J.C., Honer, W.G., & Kennedy, J.L. (2008). Brain Imaging & Behavior. Vol. 2(2): 117- 122.

A longitudinal study on the effects of typical versus atypical antipsychotic drugs on hippocampal volume in schizophrenia. Panenka, W. J., Khorram, B., Barr, A. M., Smith, G. N., Lang, D. J., Kopala, L. C., Vandorpe, R.A., & Honer, W. G. (2007). Schizophrenia Research, 94(1-3), 288-292. PMID: 17570643

Reduced anterior internal capsule and thalamic volumes in first-episode psychosis. Lang, D.J., Khorram, B., Goghari, V.M., Kopala, L.C., Vandorpe, R.A., Rui, Q., Smith, G.N. & Honer, W.G. (2006). Schiz. Res. Vol. 87:89-99. PMID: 16793239

The need for speed: an update on methamphetamine addiction. Barr, A.M., Panenka, W.J., MacEwan, G.W., Thornton, A.E., Lang, D.J., Honer, W.G., & Lecomte, T. (2006).  Journal of psychiatry & neuroscience : JPN, 31(5), 301-31. PMID: 16951733

Reduced thalamic volume in chronic schizophrenia patients after switching from typical antipsychotic medications to olanzapine. Khorram, B., Lang, D.J., Kopala, L.C., Vandorpe, R.A., Rui, Q., Smith, G.N., Goghari, V.M., Lapointe, J.S. & Honer, W.G. (2006).  Amer. J. Psychiat. Vol. 163 (11): 2005-2007. PMID: 17074955

Reduced anterior internal capsule and thalamic volumes in first-episode psychosis. Lang DJ, Khorram B, Goghari VM, Kopala LC, Vandorpe RA, Rui Q, Smith GN and Honer WG.  Schizophrenia Research. June 2006.  Impact Factor 5.1. Vol. 87:89-99.PMID: 16793239

Primary Area of Research:
Brain, Behaviour & Development

Investigator, BC Children's Hospital
Professor, Department of Psychology, Simon Fraser University
LEEF BC Leadership Chair 

Degrees / Designations
BA, M.Sc., PhD

Email: robert_mcmahon@sfu.ca
Phone: 604-875-2000 ext. 4677
Fax: 604-875-3569
Mailing Address:
BC Children's Hospital
Room A3-111
4480 Oak Street
Vancouver, BC V6H 3V4

Research Areas

  • Developmental course, assessment, prevention, and treatment of conduct problems in youth. 

  • Family based interventions for the treatment of conduct problems in young oppositional children.

About Dr. McMahon

My research focuses on understanding how conduct problems develop in children and adolescents, their developmental course over time, and how best to prevent and treat these problems, especially in the context of the family.

My current research projects include: 
Development of a new family based intervention that combines parent management training with emotion coaching for young children diagnosed with oppositional defiant disorder and who exhibit low prosocial emotions
Evaluation of the effects of Fast Track, a long-term, comprehensive intervention designed to prevent serious conduct problems in high-risk children. 
Emergence of adolescent substance use problems from the externalizing spectrum. 
Developmental pathways of conduct problems. 
Two RCTs of Connect, an attachment–based parenting intervention for the prevention and treatment of serious conduct problems in adolescent youth (age 10-16) (with Marlene Moretti).


Selected Publications

Impact of early intervention on psychopathology, crime, and well-being at age 25. Dodge K.A., Bierman K.L., Coie J.D., Greenberg M.T., Lochman J.E., McMahon R.J., & Pinderhughes E.E. for the Conduct Problems Prevention Research Group.* (2015).  American Journal of Psychiatry, 172, 59-70. DOI: 10.1176/appi.ajp.2014.13060786. PMID: 25219348

Parent management training interventions for preschool-age children. McMahon R.J. (2015, March). Rev. ed. Encyclopedia on early childhood development [online]. CEECD, SKC-ECD.

The longitudinal link between parenting and child aggression: The moderating effect of attachment security. Cyr, M., Pasalich, D.S., McMahon, R.J., & Spieker, S.J. (2014). Child Psychiatry & Human Development, 45, 555-564. DOI 10.1007/s10578-013-0424-4. PMID: 24287581

Conduct and oppositional defiant disorders. Kimonis, E., Frick, P.J., & McMahon, R.J. (2014). In E.J. Mash & R.A. Barkley (Eds.), Child psychopathology (3rd ed., pp. 145-179). New York: Guilford Press. PMID:

Evidence for a multi-dimensional latent structural model of externalizing disorders. Witkiewitz, K., King, K. M., McMahon, R. J., Wu, J., Luk, J. & the Conduct Problems Prevention Research Group.* (2013).  Journal of Abnormal Child Psychology, 41, 223-237. PMID: 22936218

The effects of the Fast Track preventive intervention on the development of conduct disorder across childhood. Conduct Problems Prevention Research Group.* (2011).  Child Development, 82, 331-345. PMID: 21291445

The impact of the Fast Track prevention trial on health services use by conduct-problem youth. Jones, D.E., Godwin, J., Dodge, K.A., Bierman, K.L., Coie, J.D., Greenberg, M.T., Lochman, J.E., McMahon, R.J., & Pinderhughes, E.E. (2010).  Pediatrics, 125, e130-e136. PMID: 20008428

Parent training for the treatment of oppositional behavior in young children: Helping the Noncompliant Child. McMahon, R.J., Long, N., & Forehand, R.L. (2010).  In R.C. Murrihy, A.D. Kidman, & T.H. Ollendick (Eds.), Handbook of clinical assessment and treatment of conduct problems in youth (pp. 163-191). New York: Springer. PMID: 25318650

Predictive validity of callous-unemotional traits measured in early adolescence with respect to multiple antisocial outcomes. McMahon, R.J., Witkiewitz, K., Kotler, J.S., & the Conduct Problems Prevention Research Group.* (2010).  Journal of Abnormal Psychology, 119, 752-763. PMID: 20939651

A parallel process growth mixture model of conduct problems and substance use with risky sexual behavior. Wu, J., Witkiewitz, K., McMahon, R.J., Dodge, K.A., & the Conduct Problems Prevention Research Group.* (2010). Drug and Alcohol Dependence, 111, 207-214. PMID: 20558013
*Members of the CPPRG (in alphabetical order) are K.L. Bierman, J.D. Coie, K.A. Dodge, E.M. Foster (from 2002-06), M.T. Greenberg, J.E. Lochman, R.J. McMahon, and E.E. Pinderhughes (from 1998).

Primary Area of Research:
Brain, Behaviour & Development
Associate Professor, Psychiatry
Faculty of Medicine, UBC

Forensic Psychiatric Services Commission (FPSC)
BC Mental Health and Substance Use Services / PHSA

E-mail: tnicholls@forensic.bc.ca
Mailing address:
70 Colony Farm Road, Coquitlam,
British Columbia, Canada, V3C 5X9

Research areas

  • Mental Illness / Substance
  • Personality disorders, Psychopathy, Schizophrenia, Suicide
  • Desistance, Forensic psychiatry/psychology, Gender, Homelessness, Protective factors, Resiliency and recovery, Risk assessment, Victimization, Violence

Keyword terms

  • Forensic, Protective factors, Schizophrenic spectrum disorders, Short-Term Assessment of Risk and Treatability (START), Victimization, Violence, Gender

About Dr. Nicholls

The intersection of law and mental health is fraught with challenges for individuals living with mental illness, their families, and for criminal justice and mental health professionals, alike. My students and I focus our scholarly work at this important juncture and concentrate our research on projects that have strong bench-to-bedside application. Our study results are intended to have direct relevance and speedy application to shaping practice and policy decisions in civil, forensic, and correctional settings. We have several large-scale programs of research:

  • Our CIHR-funded PATHWAYS study is documenting and evaluating the Redevelopment of Riverview Hospital;
  • CIHR is also funding a study of risk assessment and risk management to inform treatment planning and ultimately improve outcomes among former BC Corrections inmates and probationers;
  • We developed a concise clinical measure for the assessment and management of risk to self and others (Short-Term Assessment of Risk and Treatability, START);
  • We are also studying success and resiliency among individuals returning to the community following hospitalization and/or incarceration in jails and prison.

I am part of two national teams funded by the Mental Health Commission of Canada.The first project is studying mentally ill individuals who have come into conflict with the law and ultimately have been found 'not criminally responsible on account of mental disorder' in three Canadian provinces: Quebec, Ontario and BC (The National Trajectory Project). The second project is based on a "Housing First" approach. The At Home/Chez Soi Research Demonstration Project is investigating mental health and homelessness in five Canadian cities: Moncton, Montreal, Toronto, Winnipeg and Vancouver.

Recent Publications

View Dr. Nicholls' recent publications on ORCID

Selected Publications

The National Trajectory Project of individuals found Not Criminally Responsible on account of Mental Disorder in Canada. Crocker, A.G., Nicholls, T.L., Seto, M.C., & Cote, G. (2015).  The Canadian Journal of Psychiatry, 60(3), 96-97.


The National Trajectory Project of individuals found Not Criminally Responsible on account of Mental Disorder in Canada. Part 1: Context and methods. Crocker, A.G., Nicholls, T.L., Seto, M.C., Cote, G., Charette, Y., & Caulet, M. (2015).  The Canadian Journal of Psychiatry, 60(3), 98-105. 


The National Trajectory Project of individuals found Not Criminally Responsible on account of Mental Disorder in Canada. Part 2: The people behind the label. Crocker, A.G., Nicholls, T.L., Seto, M.C., Charette, Y., Cote, G., & Caulet, M. (2015). The Canadian Journal of Psychiatry, 60(3), 106-116. 


The National Trajectory Project of individuals found Not Criminally Responsible on account of Mental Disorder in Canada. Part 3: Trajectories and outcomes through the forensic system. Crocker, A.G., Charette, Y., Seto, M.C., Nicholls, T.L., Cote, G., & Caulet, M. (2015).The Canadian Journal of Psychiatry, 60(3), 117-126.


The National Trajectory Project of individuals found Not Criminally Responsible on account of Mental Disorder in Canada. Part 4: Criminal recidivism. Charette, Y., Crocker, A.G., Seto, M.C., Salem, L., Nicholls, T.L., & Caulet, M. (2015). The Canadian Journal of Psychiatry, 60(3), 127-134. 


The National Trajectory Project of individuals found Not Criminally Responsible on account of Mental Disorder in Canada. Part 5: How essential are gender-specific forensic psychiatric services? Nicholls, T.L., Crocker, A.G., Seto, M.C., Wilson, C., Charette, Y., & Cote, G. (2015).  The Canadian Journal of Psychiatry, 60(3), 135-145. 


The use of risk and need factors in forensic mental health decision-making and the role of gender and index offense severity. Wilson, C., Crocker, A., Nicholls, T.L., Charette, Y., & Seto, M. (2015).  Behavioral Sciences and the Law, 33, 19-25.doi: 10.1002/bsl.2162


The validity of Version 3 of the HCR-20 violence risk assessment scheme amongst offenders and civil psychiatric patients. Strub, D., Douglas, K., & Nicholls, T.L. (2014).  International Journal of Forensic Mental Health, 13(2), 148-159.


Supportive housing and forensic patient outcomes. Salem, L., Crocker, A., Charette, Y., Seto, M.C., Nicholls, T.L. & Cote, G. (2014). Law and Human Behavior.Advance online publication.doi:10.1037/lhb0000112


Dynamic and static factors associated with discharge dispositions: The National Trajectory Project of Individuals found Not Criminally Responsible on Account of Mental Disorder in Canada. Crocker, A., Nicholls, T.L., Charette, Y., & Seto, M. (2014). Behavioral Sciences and the Law, 32(5), 577-595. doi:10.1002/bsl.2133


Criminal behavior and victimization among homeless individuals with severe mental illness: a systematic review. Roy,L., Crocker, A., Nicholls, T., Reyes, A., & Latimer, E. (2014).  Psychiatric Services, 65(6), 739-750.


Predictive validity of risk assessments in juvenile offenders: Comparing the SAVRY, PCL:YV and YLS/CMI with unstructured clinical assessments. Hilterman, E., Nicholls, T., & van Nieuwenhuizen, C. (2014).  Assessment, 21(3), 324-339. doi: 10.1177/1073191113498113


Towards a national agenda on mental health and criminal justice. Seto, M. C., Crocker, A. G., Nicholls, T. L., Cote, G. (2014).  Psynopsis, 36(1), 12-13.


Personality disorders, types of violence, and stress responses in females who perpetrate intimate partner violence. Spidel, A., Greaves, C., Nicholls, T.L., Goldenson, J., & Dutton, D.G. (2013). (Special Issue on Criminal Investigative Psychology) Psychology,4(9), 5-11.


Redevelopment of tertiary psychiatric services in British Columbia: A prospective study of clinical, social, and residential outcomes of former long-stay inpatients. Petersen, K.L., Nicholls, T.L., Groden, D., Schmitz, N., Stip, E., Goldner, E.M., Arnold, L.M., & Lesage, A. (2013).  Schizophrenia Research, 149(1-3), 96-103. doi: 10.1016/j.schres.2013.05.022


Risk assessment in intimate partner violence: A review of contemporary approaches. Nicholls, T., Pritchard, M., Reeves, K, & Hilterman, E. (2013). Partner Abuse, 4(1), 77-168. doi: 10.1891/1946-6560.4.1.76


Assessment of multiple risk outcomes, strengths, and change with the START:AV: A short- term prospective study with adolescent offenders. Viljoen, J.L., Beneteau, J.L., Gulbransen, E., Brodersen, E., Desmarais, S. L., Nicholls, T. L., & Cruise, K. R. (2012).  International Journal of Forensic Mental Health, 11(3), 165-180. doi: 10.1080/14999013.2012.737406


Pilot implementation and preliminary evaluation of START:AV assessments in secure juvenile correctional facilities. Desmarais, S., Sellers, B., Viljoen, J., Cruise, C., Nicholls, T. L., & Dvoskin, J. (2012). International Journal of Forensic Mental Health, 11(3), 150-164. doi: 10.1080/14999013.2012.737405


Taking stock and taking steps: The case for an adolescent version of the Short-Term Assessment of Risk and Treatability. Viljoen, J. L., Cruise, K. R., Nicholls, T. L., Desmarais, S. L., & Webster, C. D. (2012)  International Journal of Forensic Mental Health, 11(3), 135-149. doi: 10.1080/14999013.2012.737406


Using dynamic risk and protective factors to predict inpatient aggression: Reliability and validity of START assessments. Desmarais, S., Nicholls, T. L., Wilson, C., & Brink, J. (2012). Psychological Assessment, 24(3), 685-700. doi: 10.1037/a0026668


Risk assessment instruments in clinical practice. Cote, G., Crocker, A. G., Nicholls, T. L., & Seto, M. C. (2012).Canadian Journal of Psychiatry, 57(4), 238-244


Prevalence of physical violence in intimate relationships: Part 2. Rates of male and female perpetration. Desmarais, S. L., Reeves, K. A., Nicholls, T. L., Telford, R., & Fiebert, M. S. (2012). Partner Abuse, 3(2), 170-198. doi: 10.1891/1946-6560.3.2.17


Prevalence of physical violence in intimate relationships: Part 1. Rates of male and female victimization. Desmarais, S. L., Reeves, K. A., Nicholls, T. L., Telford, R., & Fiebert, M. S. (2012).  Partner Abuse, 3(2), 140-169. doi: 10.1891/1946-6560.3.2.140


International trends in demand for forensic mental health services. Jansman-Hart, E. M., Seto, M. C. Crocker, A., G., Nicholls, T. L., & Cote, G. (2011). International Journal of Forensic Mental Health, 10(4), 326-336. doi: 10.1080/14999013.2011.625591


Resilience and successful community reintegration among female forensic psychiatric patients: A preliminary investigation. Viljoen, S., Nicholls, T.L., Greaves, C., de Ruiter, C., & Brink, J. (2011) Behavioral Sciences and the Law, 29(5), 752-770. doi: 10.1002/bsl.1001


A clinical risk profile of forensic psychiatric patients: Treatment team STARTs in a Canadian service. Nicholls, T. L., Petersen, K., Brink, J., & Webster, C. (2011). International Journal of Forensic Mental Health, 10(3), 187-199. doi: 10.1080/14999013.2011.600234


The impact of realigning a provincial tertiary hospital system on other Institutional sectors. Livingston, J. D., Nicholls, T. L., & Brink, J. (2011).  Psychiatric Services, 62(2), 200-205.


To detain or release?: Correlates of dispositions for individuals declared not criminally responsible on account of mental disorder. Crocker, A., Braithwaite, E., Cote, G., Nicholls, T., & Seto, M. (2011).  Canadian Journal of Psychiatry, 56(5), 293-302.


Protective factors in forensic psychiatry: A new frontier. de Ruiter, C. & Nicholls, T. L. (2011). Guest editor for this special issue of International Journal of Forensic Mental Health, 10(3), 160-170. doi: 10.1080/14999013.2010.534694


Individuals found Not Criminally Responsible on account of Mental Disorder: Are we providing equal protection and equivalent access to mental health services to accused mentally ill individuals across Canada? Crocker, A. G., Nicholls, T. L., Cote, G., Latimer, E., & Seto, M. C. (2010). Canadian Journal of Community Mental Health, 29(2), 55-63.

Primary Area of Research:
Brain, Behaviour & Development
Investigator, BC Children's Hospital
Assistant Professor, Department of Psychiatry
M.Sc., MD, FRCPC (Neurology), FRCPC (Psychiatry)

Email: wpanenka@mail.ubc.ca
Phone: 604-822-7549

Research Areas

  • Concussion
  • Traumatic brain injury
  • Neuroimaging
  • Addictions
  • Psychosis
  • Homeless

About Dr. Panenka

As a clinical researcher my main goals over the next five years are to continue my work with the homelessness in Vancouver’s downtown eastside, and set up a mild traumatic brain injury research program at the University of British Columbia. 

Vancouver’s downtown eastside is home to our most vulnerable population, characterized by a mixture of primary psychiatric illness and refractory addictions. As part of a large team led by Dr. Bill Honer (Head of Psychiatry) we recruit individuals housed in single room occupancy hotels who then undergo detailed medical and psychiatric testing, including brain MRI. This is a longitudinal study that follows approximately 500 individuals for up to 5 years. The data generated is important to policy makers and to science. There are a multitude of opportunities to explore psychiatric and neurological illness from many angels within this study.

My lab is concurrently funded by CIHR and Brain Canada to study traumatic brain injury. We are building a strong team that includes multiple researchers from multiple disciplines here at UBC and abroad. Under the umbrella of the BC Neuropsychiatry program we have recently started the “Neuropsychiatry Concussion Clinic” for those individuals with symptoms that do are not resolving following head trauma. This clinic and others serve as recruitment sites for research studies that focus on the development of biomarkers in concussion, which simply put means finding cognitive, imaging, and blood markers that may predict outcome and response to treatment in those with brain injuries.

Recent publications

View Dr. Panenka's recent publications on ORCID

Selected Publications


Rapid Change in Fentanyl Prevalence in a Community-Based, High-Risk Sample.
Jones AA, Jang K, Panenka WJ, Barr AM, MacEwan GW, Thornton AE, Honer WG.
JAMA Psychiatry. 2018 Mar 1;75(3):298-300. doi: 10.1001/jamapsychiatry.2017.4432. No abstract available. 
PMID: 29387869

Perceived Injustice and Its Correlates after Mild Traumatic Brain Injury.
Iverson GL, Terry DP, Karr JE, Panenka WJ, Silverberg ND.
J Neurotrauma. 2018 Mar 1. doi: 10.1089/neu.2017.5402. [Epub ahead of print]
PMID: 29239280

Attention-deficit/hyperactivity disorder is associated with baseline child sport concussion assessment tool third edition scores in child hockey players.
Collings LJ, Cook NE, Porter S, Kusch C, Sun J, Virji-Babul N, Iverson GL, Panenka WJ.
Brain Inj. 2017;31(11):1479-1485. doi: 10.1080/02699052.2017.1377351. Epub 2017 Oct 5.
PMID: 28980829

Traumatic Brain Injury in a Community-Based Cohort of Homeless and Vulnerably Housed Individuals.
Schmitt T, Thornton AE, Rawtaer I, Barr AM, Gicas KM, Lang DJ, Vertinsky AT, Rauscher A, Procyshyn RM, Buchanan T, Cheng A, MacKay S, Leonova O, Langheimer V, Field TS, Heran MK, Vila-Rodriguez F, O'Connor TA, MacEwan GW, Honer WG, Panenka WJ.
J Neurotrauma. 2017 Dec 1;34(23):3301-3310. doi: 10.1089/neu.2017.5076. Epub 2017 Sep 25.
PMID: 28741437

Autoreactivity to Sulfatide by Human Invariant NKT Cells.
Stax AM, Tuengel J, Girardi E, Kitano N, Allan LL, Liu V, Zheng D, Panenka WJ, Guillaume J, Wong CH, van Calenbergh S, Zajonc DM, van den Elzen P.
J Immunol. 2017 Jul 1;199(1):97-106. doi: 10.4049/jimmunol.1601976. Epub 2017 May 19.
PMID: 28526683

The Hotel Study-Clinical and Health Service Effectiveness in a Cohort of Homeless or Marginally Housed Persons.
Honer WG, Cervantes-Larios A, Jones AA, Vila-Rodriguez F, Montaner JS, Tran H, Nham J, Panenka WJ, Lang DJ, Thornton AE, Vertinsky T, Barr AM, Procyshyn RM, Smith GN, Buchanan T, Krajden M, Krausz M, MacEwan GW, Gicas KM, Leonova O, Langheimer V, Rauscher A, Schultz K.
Can J Psychiatry. 2017 Jul;62(7):482-492. doi: 10.1177/0706743717693781. Epub 2017 Feb 15.
PMID: 28199798

A comparison of psychotic symptoms in subjects with methamphetamine versus cocaine dependence.
Alexander PD, Gicas KM, Willi TS, Kim CN, Boyeva V, Procyshyn RM, Smith GN, Thornton AE, Panenka WJ, Jones AA, Vila-Rodriguez F, Lang DJ, William MacEwan G, Honer WG, Barr AM.
Psychopharmacology (Berl). 2017 May;234(9-10):1535-1547. doi: 10.1007/s00213-017-4551-7. Epub 2017 Feb 11.
PMID: 28190084

Cogniphobia in Mild Traumatic Brain Injury.
Silverberg ND, Iverson GL, Panenka W.
J Neurotrauma. 2017 Jul 1;34(13):2141-2146. doi: 10.1089/neu.2016.4719. Epub 2017 Feb 27.
PMID: 28114873

Systematic Review of Genetic Risk Factors for Sustaining a Mild Traumatic Brain Injury.
Panenka WJ, Gardner AJ, Dretsch MN, Crynen GC, Crawford FC, Iverson GL.
J Neurotrauma. 2017 Jul 1;34(13):2093-2099. doi: 10.1089/neu.2016.4833. Epub 2017 Feb 27.
PMID: 28100103

Primary Area of Research:
Brain, Behaviour & Development
Investigator, BC Children's Hospital
Clinical Professor, Department of Psychiatry, Faculty of Medicine, University of British Columbia

Degrees / Designations
BSc (Pharm.), MSc, Pharm. D, PhD


Email: rprocyshyn@bcmhs.bc.ca
Phone: 604-875-2000 ext. 4722
Mailing Address:
BC Children's Hospital Research Institute
Room A3-111 
950 West 28th Avenue
Vancouver, BC Canada V5Z 4H4

Research Areas

  • Antipsychotic polypharmacy

  • Clinical trials

  • Smoking and schizophrenia

About Dr. Procyshyn

My research interests are primarily in the psychopharmacology of schizophrenia. Some of my current projects include:

Antipsychotic polypharmacy in which we are studying prevalence, predictors, indicators and clinical outcomes associated with this relatively common prescribing practice that is not adequately supported by the literature or clinical practice guidelines;

Smoking and schizophrenia where we have and continue to investigate the relationship between tobacco consumption and antipsychotic treatment, self-reported motivations for why individuals with schizophrenia smoke, and predictors of starting to smoke in first episode patients;

The influence of serum lipids on clozapine’s clinical efficacy in which we are exploring possible mechanism(s) that underlie our previous work showing a positive correlation between serum triglycerides and clinical response to clozapine; and the metabolic effects of antipsychotics where we are investigating the acute and chronic effects of the atypical antipsychotics on alterations in glucose and insulin parameters.

Recent publications

View Dr. Procyshyn's recent publications on ORCID


Selected Publications

A comparison of antipsychotic drug-defined daily doses versus chlorpromazine equivalent doses in patients with or without extrapyramidal motor symptoms Barr, A. M., Honer, W. G., Johnson, J. L., Wu, T. K., & Procyshyn, R. M. (2010). .Journal of Clinical Psychopharmacology, 30(6), 741-743. PMID: 21057241

Patient Self-Care: Helping patients make therapeutic choices, (2nd Ed.) Procyshyn, R.M., & Barr, A.M. (2010). Insomnia. In: C. Repchinsky (Ed.). . Ottawa, ON: Canadian Pharmacists Association.

Persistent antipsychotic polypharmacy and excessive dosing in the community psychiatric treatment setting: A review of medication profiles in 435 canadian outpatients. Procyshyn, R. M., Honer, W. G., Wu, T. K., Ko, R. W., McIsaac, S. A., Young, A. H., Johnson, J.L., & Barr, A. M. (2010). The Journal of Clinical Psychiatry, 71(5), 566-573. PMID: 20361903

Long-acting injectable risperidone in treatment refractory patients: A 14-week open-label pilot study. Procyshyn, R. M., Barr, A. M., Flynn, S., Schenk, C., Ganesan, S., & Honer, W. G. (2010). Schizophrenia Research, 123(2-3), 273-275. PMID: 20688481

Medication errors in psychiatry: A comprehensive review. Procyshyn, R. M., Barr, A. M., Brickell, T., & Honer, W. G. (2010).  CNS Drugs, 24(7), 595-609. PMID: 20356315

Smoking cessation interventions among individuals in methadone maintenance: A brief review. Okoli, C. T., Khara, M., Procyshyn, R. M., Johnson, J. L., Barr, A. M., & Greaves, L. (2010).  Journal of Substance Abuse Treatment, 38(2), 191-199. PMID: 20015608

Differential effects of alcohol intoxication on S100B levels following traumatic brain injury. Lange, R. T., Brubacher, J. R., Iverson, G. L., Procyshyn, R. M., & Mitrovic, S. (2010). The Journal of Trauma, 68(5), 1065-1071. PMID: 20016383

Gender-specific profiles of tobacco use among non-institutionalized people with serious mental illness. Johnson, J. L., Ratner, P. A., Malchy, L. A., Okoli, C. T., Procyshyn, R. M., Bottorff, J. L., Groening, M., Schultz, A., & Osborne, M. (2010).  BMC Psychiatry, 10, 101. PMID: 2111856

Medical Manager at the Burnaby Centre for Mental Health and Addiction.
Medical specialist in Psychiatry, Psychotherapy, and Addiction Medicine.
UBC Institute of Mental Health UBC Centre for Health Evaluation & Outcome Sciences BCMHSUS.

Email: christian.schutz@ubc.ca
Phone: 778-873-4785
Address: 4214-5950 University Blvd
Vancouver, V6T1Z3

Research Areas

  • Clinical interventions and health service in substance use disorders and dual diagnoses (mental plus substance use disorders)
  • Neurobiological and neurocognitive aspects of impulsive decision making.  
  • Developmening a new transcranial magnetic stimulation paradigm 
  • Development of a better model of the addicted mind.

About Dr. Schutz

Dr. Schutz' research focusus on understanding mechanism of relapse and impulsive decision-making to improve treatment of addiction and concurrent disorders. He has published over 120 research articles and a dozen chapters.

As a clinicion, he is Medical Manager at the Burnaby Centre for Mental Health and Addiction, a 100 bed tertiary centre focused on treating individuals with severe concurrent disorders

Dr. Schutz obtained his MD from Albert-Ludwigs-University, Freiburg, Germany, PhD from Ludwig-Maximilians-University, Munich, Germany and MPH from Johns-Hopkins–University, Baltimore MD. Fellowship at NIDA/NIH, Baltimore MD (Behavioral Pharmacology), sabbatical at Yale University, New Haven, CT (Clinical Neuroscience).

Recent publications

Substance use among homeless individuals with schizophrenia and bipolar disorder.
Maremmani, A. G., Bacciardi, S., Gehring, N. D., Cambioli, L., Schütz, C., Jang, K., & Krausz, M.(2017).
The Journal of nervous and mental disease.205(3): 173-177.

Childhood Trauma and Lifetime Traumatic Brain Injury Among Individuals Who Are Homeless.
Song MJ, Nikoo M, Choi F, Schütz CG, Jang K, Krausz RM.  The Journal of head trauma rehabilitation. 2017 May.

Is bipolar disorder associated with traumatic brain injury in the homeless?
Bacciardi, S., Maremmani, A. G., Nikoo, N., Cambioli, L., Schütz, C., Jang, K., & Krausz, M.(2017). Rivista di psichiatria. 52(1): 40-46.

Chronic Pain Among Homeless Persons with Mental Illness.
Vogel, M., Frank, A., Choi, F., Strehlau, V., Nikoo, N., Nikoo, M., Hwang, S.W., Somers, J., Krausz, M.R. & Schütz, C.G.(2017).  Pain Medicine. 0: 1-9.

Effects of comorbid substance use disorders on outcomes in a Housing First intervention for homeless people with mental illness.
Urbanoski K, Veldhuizen S, Krausz M, Schutz C, Somers JM, Kirst M, Fleury MJ, Stergiopoulos V, Patterson M, Strehlau V, Goering P.  Addiction. 2018 Jan 1.

Tincture of opium for treating opioid dependence: a systematic review of safety and efficacy.
Nikoo M, Nikoo N, Anbardan SJ, Amiri A, Vogel M, Choi F, Sepehry AA, Valoojerdi B, Hooshang A, Jang K, Schütz C.  Addiction. 2017 Mar 1;112(3):415-29.

Selective attention to smoking cues in former smokers. 
Rehme AK, Bey K, Frommann I, Mogg K, Bradley BP, Bludau J, Block V, Sträter B, Schütz CG, Wagner M. European Neuropsychopharmacology. 2018 Jan 19.

Primary Area of Research: Brain, Behaviour & Development
Investigator, BC Children's Hospital
Director of Research for Child and Adolescent Psychiatry, BC Children's Hospital
Medical Director, BCCH Provincial OCD Program (POP)
Academic Affiliations
Associate Professor, Division of Clinical & Behavioural Neurosciences, Department of Psychiatry, Faculty of Medicine, University of British Columbia

Email: evelyn.stewart@ubc.ca
Phone: (604) 875-2000 ext. 4725
Mailing Address:
A3-121 950 West 28th Avenue
Vancouver, British Columbia
V5Z 4H4

Research Areas

  • Anxiety
  • Autism Spectrum Disorder
  • Depression
  • Mood Disorders
  • Obsessive-Compulsive Disorder
  • Parenting
  • Psychotic Disorders
  • Schizophrenia
  • Streptococcal Infections
  • Tourette Syndrome
  • Mental Health & Behaviour
  • Neurodevelopmental Disorders
  • Visualizing the Brain

About Dr. Stewart

Dr. Evelyn Stewart is an Associate Professor in the Department of Psychiatry, University of British Columbia and is the founding director of the Pediatric Obsessive-Compulsive Disorder Clinic and Research Program at BC Children and Women’s Health Centre. She is a clinical, genetic and neuroscience researcher, as well as a child and adolescent psychiatrist.

Her research focuses on biologic, phenotypic, familial, and treatment aspects of childhood-onset neuropsychiatric disorders, such as obsessive-compulsive disorder (OCD). Dr. Stewart has authored over 70 original papers, reviews and chapters on genetic, clinical, and treatment aspects of OCD, Tourette's Disorder, and related illnesses. She sits on the Scientific and Clinical Advisory Board of the International OCD Foundation and was previously on the Medical Advisory Board of the Tourette Syndrome Association of America and Co-director of the International OCD Foundation Genetics Collaborative.

At BCCHR, she leads the BB&D theme and co-leads the Mental Health group.

Current Projects

Neural Correlates in Childhood-onset OCD: The goal of this study is to evaluate for neurocognitive and neurosoft sign state and at-risk trait markers for OCD, by examining affected, at-risk and healthy youth.

Brain Function and Structure in Pediatric Obsessive Compulsive Disorder: The goal of this study is to examine the cortical structure and functional activation in the regions implicated in OCD in OCD-affected, OCD-unaffected siblings, and healthy children and adolescents. A planning task conducted pre- and post-symptom provocation will be used to examine the impact of symptoms on executive function. In addition, DTI will record white matter structure and organization.

As Principal Investigator:

Obsessive-Compulsive Disorder (OCD) Registry and DNA Repository
Clinical Outcomes following Group-based Family Cognitive-Behaviour Therapy in Pediatric Obsessive- Compulsive Disorder (OCD).
Mindfulness Training versus Peer Support Groups for Parents of Obsessive-Compulsive Disorder
Objective measures of sleep and daily physical activity in pediatric Obsessive-Compulsive Disorder

As Co-Investigator:

Cognitive and biological underpinnings of delusions in psychosis
Trends in Psychiatric Seasonal Emergency Admission

Grants

2010-current, NIH-RO1, Perspectives on Neuroimaging and Genetics from Parents of Children with OCD. The goal is to examine experiences of parents involved in Pediatric neuroimaging studies. Role: Co-Investigator.

2012-2020, MSFHR Clinical Research Scholar Award, $90,000/year or ($635,000 for 8 years), OCD translational multi-modal research program. The goal is to create an interdisciplinary, multimodal research program within the new Pediatric OCD clinic at B.C. Children’s Hospital. Role: Principal Investigator.

2014-2016, CIHR Operating Grant, $175,485/year ($526,454 for 3 years), Neural Correlates in Childhood-onset Obsessive-Compulsive Disorder. The goal is to compare neural correlates in CO-OCD and unaffected, at-risk sibling (SIB) groups with matched healthy controls (HC), in order to evaluate both their suitability as trait markers of genetic risk (to better understand the disorder) and their potential utility in clinical settings (to better manage the disorder). Role: Principal Investigator.

Recent Publications

View Dr. Stewart's recent publications on ORCID

Selected Publications

Long-term outcome of pediatric obsessive--compulsive disorder: a meta-analysis and qualitative review of the literature

Acta Psychiatrica Scandinavica

Stewart, SE and Geller, DA and Jenike, M and Pauls, D and Shaw, D and Mullin, B and Faraone, SV

2004


Cognitive inflexibility and frontal-cortical activation in pediatric obsessive-compulsive disorder

Journal of the American Academy of Child & Adolescent Psychiatry

Britton, Jennifer C and Rauch, Scott L and Rosso, Isabelle M and Killgore, William DS and Price, Lauren M and Ragan, Jennifer and Chosak, Anne and Hezel, Dianne M and Pine, Daniel S and Leibenluft, Ellen and others

2010


Genome-wide association study of Tourette's syndrome

Molecular psychiatry

Scharf, Jeremiah M and Yu, Dongmei and Mathews, Carol A and Neale, Benjamin M and Stewart, S Evelyn and Fagerness, Jesen A and Evans, Patrick and Gamazon, Eric and Edlund, Christopher K and Service, SK and others

2013


A Multisite Study of Family Functioning Impairment in Pediatric Obsessive-Compulsive Disorder

Journal of the American Academy of Child & Adolescent Psychiatry

S. Evelyn Stewart and Yu-Pei Hu and Aldrich Leung and Elaine Chan and Dianne M. Hezel and Sarah Yao Lin and Laura Belschner and Casey Walsh and Daniel A. Geller and David L. Pauls

DOI: 10.1016/j.jaac.2016.12.012

03/2017

Primary Area of Research:
Brain, Behaviour & Development
Investigator, BC Children's Hospital
Professor, Department of Psychology, Simon Fraser University

Email:aethornt@sfu.ca
Mailing Address:
Human Neuropsychology Laboratory 
Department of Psychology 
Simon Fraser University  
Burnaby, BC 
V5A 1S6

Research Areas

  • Clinical Neuropsychology 

  • Neuropsychological Assessment 

  • Neurocognitive Disorders in Medical and Psychiatric Patients 

  • Neuropsychology of Memory 

  • Frontal Lobe Functioning

About Dr. Thornton

My research interests are in the area of clinical neuropsychology, with a focus on memory, working memory, and executive functions. The following is a summary of my recent work:

My work in multiple sclerosis (MS) addresses controversies regarding the nature of MS-associated cognitive impairment. The research has contributed to deconstructing the popular retrieval-based account of memory dysfunction. Furthermore, previously unrecognized clinical features of MS that are associated with memory dysfunction have been elucidated.

I have an ongoing interest in the neurocognitive features of schizophrenia. This work is designed to elucidate the nature of memory impairment in schizophrenia and associations between illness-related factors and cognition.

I have strong interests in concussion and traumatic brain injury. This work is focused on determining who is at greatest risk for poor cognitive outcome following concussion. This research also evaluates the relationship between the extent of concussion exposure (single and multiple injuries) and neurocognitive impairment. Theoretically, these issues are important in understanding brain reserve capacity and threshold concepts in neuropsychology.

Recent publications

View Dr. Thornton's recent publications on ORCID

Selected Publications

Profiles of individuals seeking psychiatric help for psychotic symptoms linked to methamphetamine abuse – Baseline results from the MAPS (methamphetamine and psychosis study) Lecomte, T., Mueser, K.T., MacEwan, G.W., Laferriere-Simard, M.C., Thornton, A.E., Buchanan, T., Goldner, E., Brink, J., Ehmann, T.S., Lang, D., Kang, S., Barr, A.M., & Honer, W.G. (2010).  Mental Health Subst Abuse, 3, 168-181.

The ecological validity of everyday cognition in hospitalized patients with serious mental illness. Thornton, A.E., Kristinsson, H., DeFreitas, V.G., & Thornton W.L. (2010).  Journal of Clinical and Experimental Neuropsychology, 32:3, 299-308.

Hippocampal plasticity in response to exercise in schizophrenia. Pajonk, F. G., Wobrock, T., Gruber, O., Scherk, H., Berner, D., Kaizl, I., Kierer, A., Müller, S., Oest, M., Meyer, T., Backens, M., Schneider-Axmann, T., Thornton, A.E., Honer, W.G., & Falkai, P. (2010).  Archives of General Psychiatry, 67(2), 133-143.

A novel mechanism and treatment target for presynaptic abnormalities in specific striatal regions in schizophrenia. Barakauskas, V. E., Beasley, C. L., Barr, A. M., Ypsilanti, A. R., Li, H. Y., Thornton, A. E., Wong, H., Rosokija, G., Mann, J.J., Mancevski, B., Jakovski, Z., Davceva, N., Illevski, B., Dwork, A.J., Falkai, P., & Honer, W. G. (2010). Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 35(5), 1226-1238.

Prenatal tobacco exposure in first-episode psychosis. Smith, G.N., MacEwan, G.W., Kopala, Lang, D.J., Barr, A.M., Honer, W.G., Ehmann, T.S., Good, K., Thornton, A.E., & Neilson, H. (2010) Schizophrenia Research, 119(1-3), 271–272.

Predictors of starting to smoke cigarettes in patients with first-episode psychosis. Smith, G.N., Wong, H., MacEwan, G.W., Kopala, L.C., Ehmann, T.S., Thornton, A.E., Lang, D.J., Barr, A.M., Procyshyn, R., Austin, J.C., Flynn, S.W., & Honer, W.G. (2009). Schizophrenia Research, 108(1-3), 258-264.

The neuropsychology of multiple sclerosis. Thornton, A.E., & DeFreitas, V.G. (2009).  In I. Grant and K.M. Adams (Eds.), Neuropsychological Assessment of Neuropsychiatric and Neuromedical Disorders, 3rd Edition. Oxford University Press.

The Clozapine and Risperidone Enhancement Study Group. (2007). Changes in serum lipids, independent of weight, are associated with changes in symptoms during long-term clozapine treatment. Procyshyn, R. M., Wasan, K. M., Thornton, A. E., Barr, A. M., Chen, E. Y., Pomarol-Clotet, E., Stip, E., Williams, R., MacEwan, G.W, & Birmingham, C.L.,  Journal of Psychiatry & Neuroscience : JPN, 32(5), 331-338.

Cumulative concussion exposure in rugby players: Neurocognitive and symptomatic outcomes. Thornton, A.E., Cox D.N., Whitfield, K. & Fouladi R.T. (2008).  Journal of Clinical and Experimental Neuropsychology, 30:4, 398-409.

 MAG gene variation and cortical gray matter volume in first episode schizophrenia. Voineskos, A.N., Lang, D.J., Zai, G., Bulgin, N., Shaikh, S., Su, W., Kopala, L.C., MacEwan, G.W., Thornton, A.E., Smith, G.N., Austin, J.C., Honer, W.G., & Kennedy, J.L. (2008). Brain Imaging & Behavior., 2(2), 117-122. 

Primary Area of Research:
Brain, Behaviour & Development
Investigator, BC Children's Hospital
Assistant Professor (Partner), Department of Psychiatry, University of British Columbia
Scientific Director, Brain Dynamics Lab, UBC


Email: ctipper@bcchr.ca
Phone: 604-875-2000 ext. 4024
Mailing Address:
BC Children's Hospital Research Institute
A3-113
938 W 28th Ave
Vancouver, BC V5Z 4H4

Research Areas

  • Cognitive and social neuroscience in health and illness.
  • Quantifying organization patterns in complex brain networks for attention and social awareness.
  • Non-pharmacological neurotherapeutics discovery. 
  • EEG, fMRI, DTI, tDCS.

About Dr. Tipper

My work utilizes multimodal brain imaging along with cutting edge analytical techniques to quantify complex brain network organization and dynamics.

My primary goal is to map complex clinical phenotypes to complex anatomical, functional, and biochemical organization in brain systems that support attention and social awareness. I am building research partnerships with clinicians to better understand developmental, neuropsychiatric, and neurological disorders such as autism, attention deficit/hyperactivity disorder, anxiety, chronic pain, and traumatic brain injury. A key emphasis is to pursue avenues holding promise for the development of non-pharmacological interventions that can improve quality of life for children and families affected by these conditions. 


Current Projects

Functional brain networks of the frontoparietal attention system

Paradoxically, despite being one of the most intensively studied topics in cognitive neuroscience, “attention” remains a nebulous concept. This is because attention is not a unitary phenomenon with a single underlying brain mechanism, but rather is comprised of multiple component processes mediated cortically by a distributed network of frontal and parietal brain regions. The goal of this project is to distinguish component processes of attention and determine their neural substrates. This study utilizes fMRI and a novel application of a variance-based brain analytical technique known as constrained principal component analysis (CPCA) to identify functional brain networks that mediate the various component process of attention.

Dynamic brain networks for the integration of attention functions: A combined fMRI-EEG study

This study collected fMRI and dense-array EEG data on the same participants while they perfromed a challenging, attention-demaning task. Using a variance-based brain imaging analysis technique known as constrained principal component analysis (CPCA), we aim to identify distinct brain networks that mediate the various component processes of attention, and quantify the functional dynamics underlying their inegration. A key component of this study is the development of analytical techniques to combine the precise spatial information provided by fMRI with the precise temporal information provided by EEG.

The role of neural simulation in action understanding: A simultaneous fMRI-EEG study

This study investigates the role of agent-independent brain substrates in coding various properties of action. Previous research has revealed a functionally stratefied, hierarchiacally organized action observation brain network (AON). This network is involved in representing both executed and observed actions. There has been much debate over whether this functional overlap reflects a human "mirror neuron system". This study utilized a novel virtual reality task and an fMRI design known as repetition suppression (RS) to directly test for brain substrates that responded identically regardless of whether an action was seen or performed. EEG data collected simultaneously also enables us to chart the functional dynamics linked to the integration of distinct brain processes underlying action representation.

Brain network architechtures for multidimensional attentional control: A graph-theoretic framework

Individuals vary in how they control attention based on multiple dynamic sources of information. We tested if there are characteristic organizational features of the attention network associated with successful cognitive control over volitional orienting to changing spatial cues and the ability to adapt detection criteria given varying event probabilities. Novel and robust community detection algorithms identified groups of subjects with attention networks having similar functional modularity, defined by functional magnetic resonance imaging (fMRI). This investigation relies on the application of emerging computational techniques for quantifying human functional connectomes.

Recent Publications

For the latest publications, please visit my ORCID profile


Selected Publications

Processing narratives concerning protected values: A cross-cultural investigation of neural correlates. Kaplan, J., Gimbel, S., Dehghani, M. Immordino-Yang, M. H., Sagae, K., Wong, J., Tipper, C. M., Damasio, H., Gordon, A., & Damasio, A. (in press).  Cerebral Cortex. http://cercor.oxfordjournals.org/content/early/2016/01/06/cercor.bhv325.abstract


Altered Balance of Functional Brain Networks in Schizophrenia. Woodward, T. S., Leong, K. W., Sanford, N., Tipper, C. M., & Lavigne, K. M. (2016).  Psychiatry Research: Neuroimaging, 248, 94-104. PMID: 26786152


Body language in the brain: constructing meaning from expressive movement. Tipper, C. M., Signorini, G., & Grafton, S. T. (2015).  Frontiers in Human Neuroscience, 9:450. PMID: 26347635


 Reduced functional connectivity during controlled semantic integration in schizophrenia: A multivariate approach.  Woodward, T. S., Tipper, C. M., Leung, A., Lavigne, K. M., & Metzak, P. (2015). Human Brain Mapping, 36. 2948-2964. CA (IF 6.924). PMID: 26014890


Structurally-constrained relationships between cognitive states in the human brain. Hermundstad, A. M., Brown, K. S., Bassett, D. S., Aminoff, E. M., Frithsen, A., Johnson, A., Tipper, C. M., Miller, M. B., Grafton, S. T., & Carlson, J. M. (2014).  Public Library of Science Computational Biology, 10(5), e1003591. CA. PMID: 24830758


Structural foundations of resting-state and task-based functional connectivity in the human brain. Hermundstad, A. M., Bassett, D. S., Brown, K. S., Aminoff, E. M., Clewitt, D., Freeman, S., Frithsen, A., Johnson, A., Tipper, C. M., Miller, M. B., Grafton, S. T., & Carlson, J. M. (2013).  Proceedings of the National Academy of Sciences, 110(15), 6169-6174. CA (IF 9.809). PMID: 23530246


Escaping the here and now: Evidence for a role of the default mode network in perceptually decoupled thought. Smallwood, J., Tipper, C. M., Brown, K., Baird, B., Engen, H., Michaels, J. R., Grafton, S. T., & Schooler, J. W. (2013).  Neuroimage, 69, 120-125. CA (IF 6.956). PMID: 23261640


Decoding intention: A neuroergonomic perspective. Grafton, S. T. & Tipper, C. M. (2012). Neuroimage, 59(1), 14-24. CA (IF 6.956). PMID: 21651985


Attitudes trigger motor behavior through conditioned associations: neural and behavioral evidence. McCall, C., Tipper, C. M., Blascovich, J. B., & Grafton, S. T. (2012).  Social, Cognitive, and Affective Neuroscience, 7(7), 841-849. CA (IF 5.884). PMID: 21948955


Brain responses to biological relevance.Tipper, C. M., Handy, T. C., Giesbrecht, B., & Kingstone, A. (2008).  Journal of Cognitive Neuroscience, 20(5), 879-891. FA (IF 4.687). PMID: 18201123

Primary Area of Research:
Clinical Neuropsychological Assessment
Neuropsychological Functioning in Severe Mental Illness
Metacognition and Executive Functioning
Clinical Professor, Department of Psychiatry, Faculty of Medicine, University of British Columbia
Investigator, BC Mental Health and Substance Use Services
Clinical Neuropsychologist, BC Psychosis Program

Ph.D., R.Psych


Email: Ivan.Torres@ubc.ca
Phone: 604-822-7769
Mailing Address:
Department of Psychiatry
University of British Columbia
Room 2C7 - 2255 Wesbrook Mall
Vancouver, BC, V6T 2A1

Research Areas

  • Clinical Neuropsychology

  • Cognitive Assessment

  • Psychotic Disorders

  • Bipolar Disorders

  • Metacognition and self-awareness of cognitive deficits

About Dr. Torres

Dr. Torres is a Clinical Neuropsychologist and Clinical Professor within the Department of Psychiatry at UBC.   He has broad research interests in neuropsychological functioning in severe mental illness and other neurological disorders, and is affiliated with the BC Psychosis Program and the Mood Disorders Centre at UBC.  His research aims to better understand the nature of cognitive impairment in mood and psychotic disorders, the association between cognition and clinical and outcome variables in these illnesses, and the underlying neural substrates of these neuropsychological impairments.  He also has a focused interest in understanding executive/self-regulatory cognitive functions such as awareness of cognitive deficits in various patient populations.


Recent Publications

Methodological Recommendations for Cognition Trials in Bipolar Disorder by the International Society for Bipolar Disorders Targeting Cognition Task Force. Miskowiak, K.W., Burdick, K.E., Martinez-Aran, A., Bonnin, C.M., Bowie, C. R., Carvalho, A.F., Gallagher, P., Lafer, B., López-Jaramillo, C., Sumiyoshi, T., McIntyre, R.S., Schaffer, A., Porter, R. J., Torres, I.J., Yatham, L.N., Young, A.H., Kessing L.V., Vieta, E. (2017). Bipolar Disorders, 19(8), 614-626 doi: 10.1111/bdi.12534


Changes in brain-behavior relationships following a 3-month pilot cognitive intervention program for adults with traumatic brain injury. Porter, S., Torres, I. J., Panenka, W., Rajwani, Z., Fawcett, D., Hyder, A., & Virji-Babul, N. (2017). Heliyon, 3(8), doi: 10.1016/j.heliyon.2017. e00373


Weight gain as a predictor of frontal and temporal lobe volume loss in bipolar disorder: A prospective MRI study. Bond, D.J., Su, W., Honer, W., Dhanoa, T., Batres-y-Carr, T., Lee, S., Torres, I.J., Lam, R., & Yatham, L.N. (2019). Bipolar Disorders, 21(1), 50-60.

Inflammatory Cytokines and Cognitive Functioning in Early-Stage Bipolar I Disorder. Chakrabarty, T., Torres, I.J., Bond, D.J., & Yatham, L.N.  (2019).   Journal of Affective Disorders, 245, 679-685.


Functional Disconnectivity of the Hippocampal Network and Neural Correlates of Memory Impairment in Treatment-Resistant Depression. Ge, R., Torres, I.J., Brown, J., Gregory, E., McLellan, E., Downar, J., Blumberger, D.M.,  Daskalakis, Z.J., Lam, R.W., Vila-Rodriguez, F. (2019). Journal of Affective Disorders, 253, 248-256.

The International Consortium Investigating Neurocognition in Bipolar Disorder (ICONIC‐BD). Burdick, K. E., Millett, C. E., Bonnín, C. d., Bowie, C. R., Carvalho, A. F., Eyler, L. T., Gallagher, P. , Harvey, P. D., Kessing, L. V., Lafer, B. , Langenecker, S. A., Lewandowski, K. E., López‐Jaramillo, C. , Marshall, D. F., Martinez‐Aran, A. , McInnis, M. G., McIntyre, R. S., Miskowiak, K. W., Porter, R. J., Purdon, S. E., Ryan, K. A., Sumiyoshi, T. , Torres, I. J., Van Rheenen, T. E., Vieta, E. , Woodward, N. D., Yatham, L. N. and Young, A. H. (2019). Bipolar Disorders, 21, 6-10. doi:10.1111/bdi.12748


Selected Publications


Discrepancy between objective and subjective cognition in Major Depressive Disorder. Serra-Blasco, M., Torres, I.J., Vicent-Gil, M., Goldberg, X., Navarra-Ventura, G., Aguilar, E., Via, E., Portella, M.J., Figuereo, I., Palao, D., Lam, R., Cardoner, N. (2019). European Neuropsychopharmacology, 29(1), 46-56.


Assessing and addressing cognitive impairment in bipolar disorder: The international society for bipolar disorders targeting cognition task force recommendations for clinicians. Miskowiak, K. W., Burdick, K. E., Martinez-Aran, A., Bonnin, C. M., Bowie, C. R., Carvalho, A. F., Gallagher,P., Lafer,B., Lopez-Jaramillo,C., Sumiyoshi,T., McIntyre,R.S., Schaffer,A., Porter,R.J., Purdon,S., Torres,I.J., Yatham,L.N., Young,A.H., Kessing,L.V., & Vieta, E. (2018). Bipolar Disorders, 20(3), 184-194.


Lurasidone versus treatment as usual for cognitive impairment in euthymic patients with bipolar I disorder: a randomised, open-label, pilot study. Yatham, L. N., Mackala, S., Basivireddy, J., Ahn, S., Walji, N., Hu, C., Lam, R. W., & Torres, I.J. (2017). Lancet Psychiatry, 4(3), 208-217.


Verbal memory improvement in first-episode psychosis APOE-epsilon4 carriers: A pleiotropic effect? Vila-Rodriguez, F., Lang, D. J., Baitz, H., Gicas, K., Thornton, A. E., Ehmann, T. S., Smith,G.N., Barr,A.M., Torres,I.J., Kopala,L.C., MacEwan,G.W., Muller,D.J., Kennedy,J.L., & Honer, W. G. (2017).  Neuropsychiatric Disease and Treatment, 13, 2945-2953. 10.2147/NDT.S150488 [doi]


Metacognitive Knowledge and Experience in Recently Diagnosed Patients with Bipolar Disorder. Torres, IJ, Mackala, SA, Kozicky, JM, Yatham, LN. (2016). Journal of Clinical and Experimental Neuropsychology, 38(7), 730-744.


12-month longitudinal cognitive functioning in patients recently diagnosed with bipolar disorder. Torres, I.J., Kozicky, J., Popuri, S., Bond, D.G., Honer, W.J., Yatham, L.N.  (2014). Bipolar Disorders, 16(2), 159-171.


Grants

Co-investigator, "A 6-Week Randomised, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy of Lurasidone Adjunctive Therapy in Improving Cognitive Functioning in Euthymic Bipolar Disorder Patients (ELICE-BD)."  Unrestricted Grant, Dinippon Summitomo (PI: Lakshmi Yatham); $3,600,000 (2016-2021).


Co-investigator, "Offsetting hippocampal degeneration in moderate-severe TBI."  Canadian Traumatic Brain Injury Research Consortium (CTRC) Project Grants Competition (PI Robin Green, Will Pannenka); $40,000 (2018-2019).


Co-investigator, "Prospective Study of Clinical Outcome, Brain Morphology, Cognitive and Other Functional Outcomes in Patients after a First Episode of Mania": Unrestricted Grant, Astra Zeneca (PI: Lakshmi Yatham, M.D.); $1,437,425 (2004-2019).


Co-investigator, "Neuroimaging of brain structure and function following a cognitive intervention program for adults with TBI." MITACS Accelerate Graduate Internship Program (PI: Naznin Virji-Babul); $90,000 (2016-2017).


User Group Member, "Integrated Neurostimulation Platform for Neuropsychiatric Research": Technology Platform, Brain Canada (PI: Fidel Vila-Rodriguez); $277,500 (2014-2017).


Co-investigator, "Bipolar Disorder in Later Life: A Mixed-Methods, Experiential Sampling Study of Health and Well-Being Over Time": Operating Grant, Canadian Institutes of Health Research (PI: Norm O'Rourke, Ph.D); $722,000 (2012-2016).


Principal Investigator, "Investigation of Metacognition in Bipolar Disorder and its Association with Functional Outcome and Quality of Life": Operating Grant, Canadian Institutes of Health Research; $210,000 (2011-2016).

Primary Area of Research:
Somatization, Emotion Regulation, Interpersonal Relationships, Psychotherapy

Clinical Assistant Professor, Division of Child and Adolescent Psychiatry, UBC Medicine

Psychologist, Psychiatry Teaching and Consultation Clinic, BC Children’s Hospital

Investigator, BCMHSUS and BCCH Research Institutes


Email: amrit.dhariwal@ubc.ca
Phone: 604-875-2097
Mailing Address:

Box 141, 4500 Oak Street,

Vancouver BC V6H 3N1


About Dr. Dhariwal

Dr. Dhariwal is a clinical researcher and practicing psychologist. Her research has been focused on the longitudinal development and function of early life relationships. Her current work addresses the importance of relationships for mental and physical health among children and adolescents. She is very curious about how to optimize relationally-focused psychotherapies to reduce somatic symptoms and improve everyday functioning.


Grants

BC Children's Hospital Research Institute – BB&D Theme Catalyst Grant (2019-2021). The early developmental origins of pain-related somatization and psychiatric symptoms. $20K

 

International Centre for Excellence in Emotionally Focused Therapy (2018-2020). Emotionally focused family therapy for adolescents affected by somatization in a tertiary care setting: A feasibility study. 12K

 

BC Children's Hospital Research Institute – BB&D Theme Catalyst Grant (2018-2020). Connecting the mind and body: A mixed-method approach to explore the process of change in a multifamily treatment for adolescent somatization. $20K

 

Provincial Health Services Authority Partners in Action Grant (2019). Patient perspectives on group treatment for somatization. $2.5K


Primary Area of Research:
Parenting, Child Mental Health, Social Cognitions


Registered Psychologist, Outpatient Mental Health, BC Children’s Hospital
Clinical Assistant Professor, Department of Psychiatry UBC


BA, MA, Ph.D.


Email: jmah@bcchr.ca

Phone: 604-875-2010
Mailing Address:

Box 150, 4500 Oak Street,

Vancouver, BC, V6H 3N1


About Dr. Mah

Dr. Janet Mah is a Registered Psychologist at the BC Children’s Hospital, working in the outpatient mental health programs. She is also a Clinical Assistant Professor in the Department of Psychiatry, Faculty of Medicine at the University of British Columbia. Her clinical expertise focuses on behavioural parent training and cognitive behavioural therapy, which are evidence-based interventions for addressing attentional and behavioural difficulties, as well as anxiety and emotional regulation. She is a principal investigator at the BC Children’s Hospital Research Institute and the BC Mental Health and Substance Use Research Institute. She is also an active member of the Canadian ADHD Research Exchange, a national network of ADHD researchers. Her research focuses on parenting, beliefs and attitudes related to treatment engagement and outcomes, and mental health literacy and stigma among cultural groups.

Recent publications


Smith J, Pike I, Brussoni M, Tucker L, Masse LC, Mah JWT, Boudreau A, Mount D, Bonaguro R, Glegg S, Amed S. (2019). Mixed methods study exploring parent engagement in child health research in British Columbia. BMJ Open, e025404.

 

Jaspers-Fayer, F., Lin, S.Y., Belschner, L., Mah, J.W.T., Chan, E., Bleakley, C., … Stewart, S.E. (2018). A Case-Control Study of Sleep Disturbances in Pediatric Obsessive-Compulsive Disorder. Journal of Anxiety Disorders, 55, 1-7.


Climie, E.A., Mah, J.W.T., & Chase, C.Y. (2017). Clinical reasoning in the assessment and intervention planning of Attention-Deficit/ Hyperactivity Disorder. Canadian Journal of School Psychology, 32, 31-45.


Mah, J.W.T., & Tsang, P. (2016). Visual schedule system in dental care for patients with autism: A pilot study. Journal of Clinical Pediatric Dentistry, 40, 393-399.

Selected Publications


Graham, S.A., Nilsen, E., Mah, J.W.T., Morison, S., MacLean, K., Fisher, L., …Ames, E. (2014). An examination of communicative interactions of children from Romanian orphanages and their adoptive mothers. Canadian Journal of Behavioural Sciences, 46, 9-19.


Mah, J.W.T., & Johnston, C. (2011). Cultural variations in mothers' acceptance of and intent to use behavioral child management techniques. Journal of Child and Family Studies, 21, 486-497.


Johnston, C., Mah, J.W.T., & Regambal, M. (2010). Parenting cognitions and treatment beliefs as predictors of experience using behavioural parenting strategies in families of children with Attention-Deficit/Hyperactivity Disorder. Behavior Therapy, 41, 491-504.


Mah, J.W.T., & Johnston, C. (2008). Parental social cognitions: Considerations in the acceptability of and engagement in behavioral parent training. Clinical Child andGrants Family Psychology Review, 11, 218-236.

Grants

UNIVERSITY OF BRITISH COLUMBIA, faculty of medicine strategic investment fund                      

Project Title: Child-sized Knowledge Translation

 

BC Children's Hospital RESEARCH INSTITUTE                , Theme Catalyst grant                          

Project Title: Group behavioural treatment of selective mutism

 

CIHR eHIPP                                                                      Project Title: Teacher Help


Investigator, BC Children's Hospital

Professor, Department of Psychiatry, Faculty of Medicine, University of British Columbia

B.Sc., MA, Ph.D.

Email: todd.woodward@ubc.ca

Phone: 604-875-2000 ext. 4724

Mailing address:

BC Children's Hospital Research Institute

Room 116, 3rd Floor

938 W. 28th Avenue

Vancouver, V5Z 4H4


About Dr. Woodward

The objective of my research program is to gain a functional and anatomical understanding of the functional brain networks that underlie the primary symptoms of psychosis and schizophrenia. Three lines of research are being pursued.

First, the cognitive correlates of the symptoms of psychosis are being explored by way of originally designed cognitive paradigms assessing specific aspects of memory and reasoning. Translation of these results back to people with schizophrenia in a group setting have led to a promising treatment program called metacognitive training (MCT). Second, functional neuroimaging (fMRI, EEG, MEG) is being utilized to identify the neural underpinnings of these cognitive functions, and how their dysfunction manifests as the symptoms of psychosis, and how they are affected by MCT. Finally, software is being developed for multivariate analysis of functional neuroimaging data (fMRI-CPCA and MEG-CPCA).

Current Projects

Functional Neuroimaging

The objectives of our functional neuroimaging research are (1) to gain a functional and anatomical understanding of the cognitive systems involved in psychosis and schizophrenia, and (2) to develop new multivariate methods for analyzing fMRI data, with applications to integrating information from fMRI, EEG and MEG..

Cognitive Neuropsychiatry 

The objective of our cognitive neuropsychiatry research is to identify the cognitive operations underlying the primary symptoms of psychosis and schizophrenia. This is being explored by way of originally designed cognitive paradigms for memory confidence, source monitoring, reasoning, and semantic association.

Recent publications

Find my recent publications using my ORCID

Selected Publications

Interaction of language, auditory and memory brain networks in auditory verbal hallucinations Curčić-Blake, B., Ford, J., Hubl, D., Orlov, N., Sommer, I., Waters, F., Allen, P., Jardri, R., Woodruff, P. W., Olivier, D., Mulert, C., Woodward, T. S., & Aleman, A. (2016). . Progress in Neurobiology. PMID: 27890810

Impairment in subcortical suppression in schizophrenia: Evidence from the fBIRN oddball task. Lavigne, K., Menon, M. & Woodward, T. S. (2016).  Human Brain Mapping, 37, 4640-4653. PMID: 27477494

Acceptance of evidence-supported hypotheses generates a stronger signal from an underlying functionally-connected network. Whitman, J. C., Takane, Y., Cheung, T., Moiseev, A., Ribary, U., Ward, L. M., & Woodward, T. S. (2016).  NeuroImage, 127, 215-226. PMID: 2670277

Altered balance of functional brain networks in schizophrenia. Woodward, T. S., Leong, K, Sanford, N. Tipper, C. M. & Lavigne, K. M., & (2016).  Psychiatry Research: NeuroImaging. 248, 94-104. PMID: 26786152

Is metacognitive training for Psychosis effective? Moritz, S., Woodward, T. S., & Balzan, R. (2016). Expert Review of Neurotherapeutics, 16(2), 105-7. PMID: 26694013

Left-dominant temporal-frontal hypercoupling in schizophrenia patients with hallucinations during speech perception. Lavigne, K. M., Rapin, L. A., Metzak, P. D., Whitman, J. C., Jung, K. & Dohen, M., Lœvenbruck, H. & Woodward, T. S. (2015). Schizophrenia Bulletin, 41(1): 259-267. PMID: 24553150

 Sustained and “sleeper” effects of group metacognitive training for schizophrenia: A randomized clinical trial. Moritz, S., Veckenstedt, R., Bohn, F., Hottenrott, B., Andreou, C., Leighton, L., Köther, U., Woodward, T. S., Treszl, A., Menon, M., Viertel, B., Pfueller, U., & Roesch-Ely, D. (2014).  JAMA: Psychiatry, 71(10), 1103-1111. PMID: 25103718

Symptom dimensions of the Psychotic Symptom Rating Scales in psychosis: A multi-site study. Woodward, T. S., Jung, K., Hwang, H., Yin, J., Taylor, L., Menon, M., Peters, E., Kuipers, E., Waters, F., Lecomte, T., Sommer, I., Daalman, K., van Lutterveld, R., Hubl, D., Kindler, J., Homan, P., Badcock, J. C., Chhabra, S., Cella, M., Keedy, S., Allen, P., Mechelli, A., Preti, A., Siddi, S. & Erickson, D. (2014). Schizophrenia Bulletin, 40(S4), S265–S274. PMID: 24936086

Symptom Changes in Five Dimensions of the Positive and Negative Syndrome Scales in Refractory Psychosis. Woodward, T. S., Jung, K., Smith, G., Hwang, H., Barr, A. M.,  Procyshyn, R. M., Flynn, S., van der Gaag, M., & Honer, W. G. (2014).  European Archives of Psychiatry and Clinical Neuroscience, 264, 673-682. PMID: 24126470

 Impaired Integration of Disambiguating Evidence in Delusional Schizophrenia Patients. Sanford, N., Veckenstedt,R., Moritz, S., Balzan, R., & Woodward, T. S. (2014).Psychological Medicine, 44(13), 2729-2738. PMID: 25065271

 Complementary Group Metacognitive Training (MCT) reduces delusional ideation in schizophrenia. Moritz, S., Veckenstedt, R., Bohn, F., Hottenrott, B., Scheu, F., Randjbar, S., Aghotor, J., Köther, U., Woodward, T. S., Treszl, A., Andreou, C., Pfueller, U., & Roesch-Ely, D. (2013). Schizophrenia Research, 151, 61-69. PMID: 24183707

Neonatal pain-related stress predicts cortical thickness at age 7 years in children born very preterm. Ranger, M., Chau, C. M., Garg, A., Woodward, T. S., Beg, M. F, Bjornson, B., Poskitt, K., Fitzpatrick, K., Synnes, A. R., Miller, S. P., Grunau, R. E. (2013).  PLOS ONE, 8(10), e76702. PMID: 24204657

Change in jumping to conclusions linked to change in delusions in early psychosis. Sanford, N., Woodward, T. S., Lecomte, T., Leclerc, C. & Wykes, T. (2013).  Schizophrenia Research, 147, 207-208. PMID: 23561297

Functional connectivity in a frontoparietal network involving the dorsal anterior cingulate cortex underlies decisions to accept a hypothesis. Whitman, J. C., Metzak, P. D., Lavigne, K. & Woodward, T. S. (2013).  Neuropsychologia, 51(6), 1132-1141. PMID: 23474076

Epoch-specific functional networks involved in working memory. Woodward, T. S., Feredoes, E., Metzak, P. D., Takane, Y. & Manoach, D. S. (2013).  Neuroimage, 65: 529-539. PMID: 23041527



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