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Neurocognition in Pediatric Obsessive Compulsive Disorder

 
Phase I: To examine the neurocognitive functioning of children and youth with OCD, their siblings, and healthy controls.
Phase II: The purpose of the study is to examine health status and quality of life of the participants in Phase I after 5 years.

Overview

Phase I

The primary outcome of this research is to further the understanding of the neurocognitive aspects that may influence the clinical status and functioning of OCD-affected children/youth to help guide treatment management as well as assist in understanding the heritability of cognitive traits in OCD. 

Phase II

This study is a 5-year follow-up study of a group of children with childhood onset obsessive compulsive disorder (CO-OCD), unaffected at-risk siblings, and those who were healthy (= no lifetime history of a psychiatric disorder) at study time point 1.   CO-OCD is a critical form of OCD because it can interfere with key aspects of neurodevelopment. We know that (i) OCD groups show brain structure and functional differences compared with typically developing individuals; (ii) CO-OCD has notably higher heritability rates than does adult OCD; and (iii) siblings are at a 10-fold increased risk for OCD.

However, despite international efforts, risk and resilience factors in CO-OCD remain elusive.
We propose to conduct a longitudinal study to identify OCD risk markers, to improve prediction models and earlier identification of OCD, and to refine treatment strategies.

Study procedures

Phase I

All participants are screened and their parents interviewed for the study using the Anxiety Disorder Interview Schedule (ADIS- parent interview) to establish lifetime psychiatric diagnoses and eligibility criteria. In the week prior to the study appointment, each participant and a parent will be asked to complete a number of questionnaires using REDCap. These questionnaires will be the BRIEF-SR and FOCI-SR/CY-BOCS for participants, and the BRIEF-PR and questions on academic background and medication and treatment history for parents. 

The study appointment will require a 1.5 to 3-hour commitment, depending on participant group and selection of optional study components. A certified school psychologist and research assistants with experience in cognitive and neuropsychological assessment and the assessment of neurological soft signs will conduct the assessment, using the following validated tools:

- The Tanner scale of physical development at their study                   appointment 

- The Wechsler Abbreviated Scale of Intelligence, Second                     Edition (WASI-II

- Selected tests from the Cambridge Neuropsychological Test          Automated Battery (CANTAB, Cambridge Cognition)

- The A-State scale from the State-Trait Anxiety Inventory for          Children (STAIC; ages 10-14) or the State-Trait Anxiety          Inventory (STAI; ages 15-18)

- Bias Against Disconfirmatory Evidence (BADE) 

- The Cambridge Neurological Inventory (CNI)

- The University of Sao Paulo's Sensory Phenomena Scale    (USP-  SPS) 

- Kaufman Test of Educational Achievement, Second Edition    (KTEA-3) 

Phase II

The ADIS diagnostic interview will be administered to the parent or to the now adult participant andREDCap questionnaires including additional OCD-related measures will be sent prior to the study appointment.  In the in-person neurocognitive assessment all three groups will complete the same assessment battery completed in phase I of this study. 


Potential benefits

Phase I

If requested, a written report with the results of this assessment is mailed to the families’ home. This report is written by a certified school psychologist with extensive experience in reporting back test results to families. 

In addition, it is anticipated that findings from this study will help to advance psychiatric research generally and knowledge of OCD in particular.  

Phase II

If requested, a written report with the results of this assessment is mailed to the families’ home. This report is written by a certified school psychologist with extensive experience in reporting back test results to families. 

The study will enable crucial examination of the interplay between risk and resiliency factors, brain development, and CO-OCD. Clarification of these aspects will facilitate earlier identification and improved management of CO-OCD. 





SOURCE: Neurocognition in Pediatric Obsessive Compulsive Disorder ( )
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